BGMP is a repository of human blood group gene mutations, phenotypic data, and immunity-related molecular information derived from the systematic curation of clinical datasets, genetic sequencing results, and literature-based research findings. Since its pioneering launch as BGMP 1.0 (2025), the database has become indispensable for transfusion medicine, clinical immunology, and precision healthcare research.

Here, we present BGMP 2.0 - an expanded update that builds on the 1.0 framework by enriching its variant annotation library with 7 ABO alleles, 1 H allele, 2 ATPC alleles, 2 MAL alleles, an additional 25 CD36 variants (22 belonging to the red blood cell group system and 3 platelet-associated ones), 1 KEL variant, 3 RHAG variants, and 18 human neutrophil antigens (HNAs). This targeted expansion addresses gaps in multi-system blood group coverage, unifying more comprehensive allele information under its standardized data framework.

BGMP 2.0 retains the 1.0 features (allele profile visualization, phenotype-frequency correlation, functional prediction, etc.) while enhancing data depth for key blood group/immunity systems. It strengthens support for clinical transfusion safety assessment and biomarker discovery for immune-related diseases, reflecting advances in blood group immunogenetics data curation.